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KMID : 0364820190550020112
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Korean Journal of Microbiology
2019 Volume.55 No. 2 p.112 ~ p.116
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Effects of SPAC1B3.08, ortholog of Thp1/PCID2, on mRNA export in fission yeast
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Park Jin-Hee
Yoon Jin-Ho
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Abstract
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Thp1/PCID2 is a subunit of the evolutionally conserved TREX-2complex, which is required for transcription-coupled mRNAexport from the nucleus to the cytoplasm. In fission yeast,Schizosaccharomyces pombe, there are two orthologs of theThp1/PCID2 protein. In addition to pci2 (SPBC1105.07c) gene,SPAC1B3.08 gene encodes a PCI domain-containing proteinthat is predicted as a component of TREX-2 complex. Overexpressionof SPAC1B3.08 cause slight defects of both growthand mRNA export. Yeast two-hybrid and co-immunoprecipitationanalysis exhibits that the SPAC1B3.08 protein interacted withSac3 and Dss1, which are another components of TREX-2complex. These observations support the possibility that the S. pombe SPAC1B3.08 protein, as a component of TREX-2complex, is involved in mRNA export.
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KEYWORD
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S. pombe, mRNA export, orthologs of Thp1/PCID2, TREX-2 complex
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